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    Usage Guidelines (Part II)

    This section is intended as a supplement to Part I.

    Divergences in Dosing Schedules

    Most people writing in seem to be replicating the dosing strategems given in the Guidelines I but there are some divergences that include the following: 

    Randy may have repeated weekly dosings over several months, though he let 3-4 weeks pass between weekly dosings. He claimed excellent results, but this writer could have misunderstood the dosing schedule used by Randy. 

    Jennifer appears to have gotten excellent results with every other day dosing with artemisinin without artesunate (she was using other things, but there is good reason to suppose the effect was due to the artemisinin). It seemed to have cleared some bronchial papillomas, and she reports that the results seem to be holding.

    Sherry (described in Novel Therapies>Patient Reports) is using an entirely different dosing strategy that includes low dose artemether. It seems to have cleared tracheal papillomas. At some point, we may(??) be offering her "alternative dosing" schedule on this website, but artemether may itself be problematic if patients do not carefully follow directions.

    Other schedules may work equally well, but if patients wish to deviate from the guidelines listed here, they should be very, very careful. The application of a new dosing schedule should be well-reasoned and discussed with one's physician. Please be clear in any self-reporting that it's "your" schedule you are following, not that of the guidelines presented on this website.

    Timing of ART When Used Right After Surgery

    Somewhere in an initial version of Part I, it was suggested that patients may want to wait a week after surgery before starting ART.  This writer initially did, and it was suggested that if people wanted to follow what he did, this is the route they may wish to consider.

    His reasoning in waiting a week was to mitigate any "unknown effects" from the ART involving necrosis. Since ART's mechanism of action is through the technical process of apoptosis, not necrosis, he now believes that it is probably safe (??) to take ART even sooner after surgery. That doesn't mean there will be a beneficial effect to doing that, however. More study on that is needed.

    Side-Effects and Brain Functioning

    In the initial versions of Part I, it was stated that no serious side-effects seemed to be attached to artemisinin and artesunate in the dosing range that was used.

    We are NOT suggesting that side-effects are impossible, however, and the use of ART on an every month basis has never been systematically studied to the best of our knowledge.

    After taking a week of ART, one may feel some slight fatigue, insomnia, over-sensitivity to the sun, etc. We would still characterize these as usually very minor, if they appear at all. 

    But according to experts at the University of Washington, all three forms of ART (artemisinin, artesunate and artemether) do cross the blood-brain barrier. What of the patient whose personality is already predisposed to schizophrenia, major depression,  bipolar disorder, serious panic attacks, anger management problems or a sleep disorder?

    This writer knows of no authoritatively documented studies suggesting this kind of side-effect profile, but it is presumptuous to say that dosing with ART could not exacerbate a disorder of this nature.

    We would hypothesize that for someone who already has disorder of this kind, ART might lead to some unpredictable results. Of course, the same thing could be said for antihistamines,  antibiotics or shellfish.

    In the end all that we can say is that no one should rule out idiosyncratic reactions.

    If there were a serious side-effect profile for ART, however, one would think it would have already shown up in the literature, some of which is sited under the Learn>Novel Therapy section of this website. This body of literature suggests that the use of ART, when taken appropriately and in coordination with your physician, is pretty safe, at least for most people.

    Taking it every month for three days on a chronic-use basis does not seem overly risky or excessive, at least intuitively. As with most things in medicine, however, much more research will need to be conducted to make such a statement with absolute confidence.